Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Toivola DM, Tao GZ, Habtezion A, Liao J, Omary MB
Publiceringsår: 2005
Tidskrift: Trends in Cell Biology
Tidskriftsakronym: TRENDS CELL BIOL
Volym: 15
Nummer: 11
Artikelns första sida, sidnummer: 608
Artikelns sista sida, sidnummer: 617
Antal sidor: 10
ISSN: 0962-8924


Intermediate filament proteins (IFs) maintain cell and tissue integrity, based on evidence of their polymerization and mechanical properties, abundance and disease-associated phenotypes. This 'traditional' function is now augmented by organelle-related and protein-targeting roles. Mitochondrial location and function depend on intact IFs, as demonstrated for desmin, keratins and neurofilaments. Golgi positioning is regulated by several IFs, and endosomal/lysosomal protein distribution by vimentin. IFs dramatically affect nuclear function and shape and play a role in subcellular and membrane targeting of proteins. These functions have been noted in tissues but in some cases only in cell culture. The IF-related organelle-specific and protein-targeting roles, which are likely interrelated, provide functions beyond cell scaffolding and integrity and contribute to the cytoprotective and tissue-specific functions of IF proteins.

Senast uppdaterad 2020-26-05 vid 05:47