Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Zhong RB, Tang Q, Wang SP, Zhang HB, Zhang F, Xiao MS, Man TT, Qu XM, Li L, Zhang WJ, Pei H
Publication year: 2018
Journal: Advanced Materials
Journal acronym: ADV MATER
Volume number: 30
Issue number: 12
Number of pages: 8
ISSN: 0935-9648


Conducting hydrogels provide great potential for creating designer shape-morphing architectures for biomedical applications owing to their unique solid-liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme-like activity that can be used as ink to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self-assembled from guanosine (G) and KB(OH)(4) with simultaneous incorporation of hemin into the G-quartet scaffold, giving rise to significant enzyme-like activity. The rapid switching between the sol and gel states responsive to shear stress enables free-form fabrication of different patterns. Furthermore, the replication of the G-quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics.


enzyme mimicking, flexible electrochemical sensors, guanosine, low-molecular-weight hydrogels, self-assembly


Last updated on 2020-04-08 at 05:47

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