Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Zhong RB, Tang Q, Wang SP, Zhang HB, Zhang F, Xiao MS, Man TT, Qu XM, Li L, Zhang WJ, Pei H
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2018
Journal: Advanced Materials
Journal acronym: ADV MATER
Volume number: 30
Issue number: 12
Number of pages: 8
ISSN: 0935-9648


Abstract

Conducting hydrogels provide great potential for creating designer shape-morphing architectures for biomedical applications owing to their unique solid-liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme-like activity that can be used as ink to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self-assembled from guanosine (G) and KB(OH)(4) with simultaneous incorporation of hemin into the G-quartet scaffold, giving rise to significant enzyme-like activity. The rapid switching between the sol and gel states responsive to shear stress enables free-form fabrication of different patterns. Furthermore, the replication of the G-quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics.


Keywords

enzyme mimicking, flexible electrochemical sensors, guanosine, low-molecular-weight hydrogels, self-assembly


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Last updated on 2019-14-10 at 06:37