Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Din MU, Saari T, Raiko J, Kudomi N, Maurer SF, Lahesmaa M, Fromme T, Amri EZ, Klingenspor M, Solin O, Nuutila P, Virtanen KA
Publisher: CELL PRESS
Publication year: 2018
Journal: Cell Metabolism
Journal acronym: CELL METAB
Volume number: 28
Issue number: 2
Start page: 207
End page: 216
Number of pages: 13
ISSN: 1550-4131


Abstract

Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress. Postprandial NEFA uptake into BAT is minimal, possibly due to elevated plasma insulin inhibiting lipolysis. However, the variation in postprandial NEFA uptake is linked to BAT thermogenesis. We identified several genes participating in lipid metabolism to be expressed at higher levels in BAT compared with white fat in postprandial state, and to be positively correlated with BAT UCP1 expression. These findings suggest that substrates preferred by BAT in postprandial state are glucose or LPL-released NEFAs due to insulin stimulation.

Last updated on 2019-19-10 at 03:38