Physical Activity in Preventing Alzheimer's Disease and Cognitive Decline: A Narrative Review

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Stefano BriniHamid, R. SohrabiJeremiah, J. Peiffer, Mira Karrasch, Heikki Hämäläinen, Ralph N. Martins, Timothy J. Fairchild
Publisher: ADIS INT LTD
Publication year: 2018
Journal: Sports Medicine
Journal acronym: SPORTS MED
Volume number: 48
Issue number: 1
Start page: 29
End page: 44
Number of pages: 16
ISSN: 0112-1642
eISSN: 1179-2035


A large body of epidemiological and experimental data exploring the relationship between physical activity (PA) and Alzheimer's disease (AD) are now available. Despite observational evidence supporting a role for PA in delaying the onset of AD, randomised controlled trials have reported mixed findings, likely due to the heterogeneity in study cohorts, outcome measures, and the adopted PA intervention. The primary objective of this narrative review is to evaluate the extant evidence on the relationship between PA, cognitive decline and AD in older populations. The interaction between PA and the putative mechanisms underlying AD progression, including genetic factors and amyloid-beta levels will be explored. In this context, particular attention will be given to studies assessing PA in the early clinical and preclinical, asymptomatic stages of AD. Based on current evidence, clinical considerations for implementation of exercise-based interventions are discussed, along with limitations of previous research and directions for future studies.

Last updated on 2020-24-09 at 03:31