Oxyethylene chain-cation complexation; Nonionic polyoxyethylene detergents attain a positive charge and demonstrate electrostatic head group interactions

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Hagerstrand H, Bobacka J, Bobrowska-Hagerstrand M, Kralj-Iglic V, Fosnaric M, Iglic A
Publication year: 2001
Journal: Cellular and Molecular Biology Letters
Journal acronym: CELL MOL BIOL LETT
Volume number: 6
Start page: 161
End page: 165
Number of pages: 5
ISSN: 1425-8153


We report literature data indicating that the polyoxyethylene chain of polyoxyethylene detergents attracts cations via dipole-ion interactions thereby attaining a positive charge character. This implies that nonionic polyoxyethylene detergents like Triton X-100 and C12E8 may interact electrostatically with phospholipid head groups. We describe how a positive charge character of Triton X-100 and C12E8 can explain their hitherto mysterious stomatocytogenic shape altering effect in human erythrocytes.


CmEn, erythrocyte membrane, PEG, polyoxyethylene, shape change, Triton X-100

Last updated on 2020-18-01 at 04:21