Renewable poly (δ-decalactone) based block copolymer micelles as drug delivery vehicle: in vitro and in vivo evaluation

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Bansal KK, Gupta J, Rosling A, Rosenholm JM
Förläggare: Elsevier
Publiceringsår: 2018
Tidskrift: Saudi Pharmaceutical Journal
Volym: 26
Nummer: 3
Artikelns första sida, sidnummer: 358
Artikelns sista sida, sidnummer: 368
ISSN: 1319-0164


Abstrakt

Polymers from natural resources are attracting much
attention in various fields including drug delivery as green
alternatives to fossil fuel based polymers. In this quest, novel block copolymers
based on renewable poly(δ-decalactone) (PDL) were evaluated for their
drug delivery capabilities and compared with a fossil fuel based polymer
i.e. methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-b-PCL).
Using curcumin as a hydrophobic drug model, micelles
of PDL block copolymers with different orientation i.e. AB
(mPEG-b-PDL), ABA (PDL-b-PEG-b-PDL), ABC
(mPEG-b-PDL-b-poly(pentadecalactone) and (mPEG-b-PCL) were prepared by
nanoprecipitation method. The size, drug loading and curcumin stability
studies results indicated that mPEG-b-PDL micelles was comparable to its
counterpart mPEG-b-PCL micelles towards improved delivery of curcumin.
Therefore, mixed micelles using these two copolymers were also evaluated
to see any change in size, loading and drug release.
Drug release studies proposed that sustained release can be obtained
using poly(pentadecalactone) as crystalline core whereas rapid release
can be achieved using amorphous PDL core. Further, mPEG-b-PDL micelles
were found to be non-haemolytic, up to the concentration of 40 mg/mL. In vivo
toxicity studies on rats advised low-toxic behaviour of these micelles
up to 400 mg/kg dose, as evident by histopathological and biochemical
analysis. In summary, it is anticipated that mPEG-b-PDL block copolymer
micelles could serve as a renewable alternative for mPEG-b-PCL
copolymers in drug delivery applications.


Nyckelord

Biodegradable polymers, controlled release, Drug delivery

Senast uppdaterad 2019-17-11 vid 03:29