JNK Regulation of Depression and Anxiety.

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Patrik Hollos, Francesca Marchisella, Eleanor T. Coffey
Publication year: 2018
Journal: Brain Plasticity
Journal acronym: Brain Plast
Volume number: 3
Issue number: 2
Start page: 145
End page: 155
ISSN: 2213-6312


Depression and anxiety are the most common mood disorders affecting 300 million sufferers worldwide. Maladaptive changes in the neuroendocrine stress response is cited as the most common underlying cause, though how the circuits underlying this response are controlled at the molecular level, remains largely unknown. Approximately 40% of patients do not respond to current treatments, indicating that untapped mechanisms exist. Here we review recent evidence implicating JNK in the control of anxiety and depressive-like behavior with a particular focus on its action in immature granule cells of the hippocampal neurogenic niche and the potential for therapeutic targeting for affective disorders.

Last updated on 2020-26-01 at 03:04