Instant decisions: transcription-independent control of death-receptor-mediated apoptosis

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Tran, Meinander, Eriksson
Publication year: 2004
Journal: Trends in Biochemical Sciences
Journal acronym: Trends Biochem Sci
Volume number: 29
Issue number: 11
Start page: 601
End page: 608
ISSN: 0968-0004
eISSN: 0167-7640


Transcription-independent modulation of signaling mediated by death receptors (DRs) has emerged as an important determinant of cell survival during both development and cellular homeostasis. Frequently, a given DR signal must be redirected rapidly either to inhibit or to potentiate the apoptotic response. This process requires immediate, protein-synthesis-independent modifications of the regulatory molecules involved. Numerous mechanisms have been shown to regulate DR responses without engaging the apoptosis-directing transcription machinery. These mechanisms involve key posttranslational modifications such as phosphorylation, ubiquitination and proteolytic degradation, all of which affect the activities of proteins at different levels in the DR signaling pathways. Changes in the organization of regulatory molecules and in their interactions with other factors also affect the DR signaling pathways. The balance between these modulatory signals rapidly decides the fate of a cell.

Last updated on 2020-01-06 at 03:50