Cell selective cytotoxicity of a peptide toxin from the cyanobacterium Microcystis aeruginosa

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Eriksson, Hägerstrand, Isomaa
Publiceringsår: 1987
Tidskrift: BBA - Biochimica et Biophysica Acta
Tidskriftsakronym: Biochim Biophys Acta
Volym: 930
Nummer: 3
Artikelns första sida, sidnummer: 304
Artikelns sista sida, sidnummer: 310
ISSN: 0006-3002


Abstrakt

The effects of a cyclic peptide toxin, isolated from the cyanobacterium Microcystis aeruginosa, on cell morphology and ion transport in human erythrocytes, isolated rat hepatocytes and mouse fibroblasts (3T3) were studied. Neither in erythrocytes nor in fibroblasts did the toxin cause morphological alterations. In hepatocytes the toxin induced marked morphological alterations at a concentration of about 50 nM. In erythrocytes and fibroblasts no effects on ion transport were observed. In hepatocytes the toxin induced a significant increase in both phosphate and potassium efflux at concentrations far below the concentration causing morphological alterations (0.1 and 1 nM, respectively). It is suggested that the cytotoxicity of the toxin is not due to a non-specific interaction with the plasma membrane and that the effects of the toxin in hepatocytes are probably due to an interaction of the toxin with cytoskeletal elements.

Senast uppdaterad 2019-22-10 vid 04:51