Intermediate filaments as signaling platforms

A2 Granskningsartikel, litteraturgranskning, systematisk granskning


Interna författare/redaktörer


Publikationens författare: Pallari, Eriksson
Publiceringsår: 2006
Tidskrift: Science's STKE : signal transduction knowledge environment
Tidskriftsakronym: Sci STKE
Nummer: 366
ISSN: 1525-8882


Abstrakt

Intermediate filaments (IFs) are cytoskeletal structures that are crucial for maintaining the structural and mechanical integrity of cells and tissues. Intriguingly, a wide range of previously unknown nonmechanical roles for the IF cytoskeleton are emerging: Recent studies have linked IFs to the integration of signals related to the determination of cell size, the regulation of cell migration and cell survival, and the buffering of the effects of stress-activated kinases. The characteristic structural features and expression patterns of the different members of this diverse family of highly abundant proteins make them well suited to act as cell- and tissue-specific modifiers and organizers of signaling.

Senast uppdaterad 2019-08-12 vid 03:19