Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Eriksson, Meriluoto, Kujari, Österlund, Fagerlund, Hällbom
Publiceringsår: 1988
Tidskrift: Toxicon
Tidskriftsakronym: Toxicon
Volym: 26
Nummer: 2
Artikelns första sida, sidnummer: 161
Artikelns sista sida, sidnummer: 166
ISSN: 0041-0101
eISSN: 1879-3150


A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

Senast uppdaterad 2020-09-08 vid 05:11