Introducing intermediate filaments: from discovery to disease

A2 Granskningsartikel, litteraturgranskning, systematisk granskning

Interna författare/redaktörer

Publikationens författare: Eriksson, Dechat, Grin, Helfand, Mendez, Pallari, Goldman
Publiceringsår: 2009
Tidskrift: Journal of Clinical Investigation
Tidskriftsakronym: J Clin Invest
Volym: 119
Nummer: 7
Artikelns första sida, sidnummer: 1763
Artikelns sista sida, sidnummer: 1771
ISSN: 0021-9738
eISSN: 1558-8238


It took more than 100 years before it was established that the proteins that form intermediate filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in virtually all differentiated cells and present both in the cytoplasm and in the nucleus. However, during the past 2 decades, knowledge regarding the functions of these structures has been expanding rapidly. Many disease-related roles of IFs have been revealed. In some cases, the molecular mechanisms underlying these diseases reflect disturbances in the functions traditionally assigned to IFs, i.e., maintenance of structural and mechanical integrity of cells and tissues. However, many disease conditions seem to link to the nonmechanical functions of IFs, many of which have been defined only in the past few years.

Senast uppdaterad 2020-29-09 vid 04:45