Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Raitio, Salo, Nevalainen, Poso, Järvinen
Publication year: 2005
Journal: Current Medicinal Chemistry
Journal acronym: Curr Med Chem
Volume number: 12
Issue number: 10
Start page: 1217
End page: 1237
ISSN: 0929-8673
eISSN: 1875-533X


Since the discovery of the cannabinoid CB2 receptor in 1993, there has been a growing interest to clarify the importance of this G-protein coupled receptor (GPCR) for human physiology, and to investigate it as a possible target for current and future drug development. Several mutation studies have examined the receptor activation and structure of the receptor binding cavity. Additionally, 3D models for the CB2 receptor have been constructed to aid in perceiving important ligand-receptor interactions. In recent years, many research groups have succeeded in synthesizing new CB2 selective ligands. This review focuses on (i) important features for ligand recognition and/or receptor activation at CB2, derived from mutation and modeling studies, and (ii) recent advances in the field of CB2 selective ligands.

Last updated on 2020-29-09 at 04:09