Reductive N-methylation of amines using dimethyl carbonate and molecular hydrogen: Mechanistic insights through kinetic modelling

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Jose R. Cabrero-Antonino, Rosa Adam, Johan Wärnå, Dmitry Yu. Murzin, Matthias Beller
Publication year: 2018
Journal: Chemical Engineering Journal
Journal acronym: Chem. Eng. J.
Volume number: 351
Start page: 1129
End page: 1136
eISSN: 1873-3212


Kinetic analysis of ruthenium-catalyzed reductive N-methylation of amines using dimethyl carbonate as C1 source and molecular hydrogen as reductant has been performed. Kinetic equations have been derived and kinetic modelling has been performed for experimental data generated previously at a constant hydrogen pressure as well as for additional experiments performed at different hydrogen pressures. The study has revealed interesting kinetic features related to an induction period strongly influenced by temperature. A kinetic model has been proposed based on advanced reaction mechanism featuring transformation between different type of catalytic species and inactivation of them during the reaction. Kinetic modelling was done for all data sets together showing excellent correspondence between calculations and experiments.


Chemical Engineering

Last updated on 2020-30-03 at 07:07