Brain oscillatory responses to an auditory-verbal working memory task in mild cognitive impairment and Alzheimer's disease

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Karrasch M, Laine M, Rinne JO, Rapinoja P, Sinerva E, Krause CM
Publisher: ELSEVIER SCIENCE BV
Publication year: 2006
Journal: International Journal of Psychophysiology
Journal acronym: INT J PSYCHOPHYSIOL
Volume number: 59
Issue number: 2
Start page: 168
End page: 178
Number of pages: 11
ISSN: 0167-8760


Abstract

We report preliminary findings oil EEG oscillatory correlates of working memory in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Event-related desynchronization (ERD) and synchronization (ERS) of the 1-20 Hz EEG frequencies were studied using wavelet transforms in elderly controls, MCI patients and mild probable AD patients performing an auditory-verbal Sternberg memory task. Behaviourally, the AD patients made more errors than the controls and the MCI group. Statistically significant differences during the encoding of the memory set were found between the controls and the MCI group, such that the latter group showed ERD in the similar to 10-20 Hz frequencies. The findings may reflect different.. compensatory encoding strategies in MCI. During retrieval, the most obvious differences were observed between the controls and the AD group: the ERD in the similar to 7-17 Hz frequencies was absent in the AD group particularly in anterior and left temporal electrode locations. This finding might indicate that AD is associated with deficient lexical-semantic processing during the retrieval phase in working memory tasks. Future studies with larger patient groups are needed to establish the diagnostic value of ERD/ERS patterns in MCI and AD. (c) 2005 Elsevier B.V. All rights reserved.


Keywords

1-20 Hz, Alzheimer's disease, EEG, event-related desynchronization, event-related synchronization, memory, mild cognitive impairment

Last updated on 2019-13-11 at 05:16