Cognitive Decline and Amyloid Accumulation in Patients with Mild Cognitive Impairment

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Koivunen J, Karrasch M, Scheinin NM, Aalto S, Vahlberg T, Någren K, Helin S, Viitanen M, Rinne JO
Publisher: KARGER
Publication year: 2012
Journal: Dementia and Geriatric Cognitive Disorders
Journal acronym: DEMENT GERIATR COGN
Volume number: 34
Issue number: 1
Start page: 31
End page: 37
Number of pages: 7
ISSN: 1420-8008


Abstract

Background/Aims: The relationship between baseline 11C-Pittsburgh compound B (C-11-PIB) uptake and cognitive decline during a 2-year follow-up was studied in 9 patients with mild cognitive impairment (MCI) who converted to Alzheimer's disease (AD) and 7 who remained with MCI. Methods: 11C-PIB PET scan was conducted at baseline and cognitive assessment both at baseline and at follow-up. To obtain quantitative regional values of 11C-PIB uptake, automated region of interest analysis was done using spatially normalized parametric ratio (region-to-cerebellar cortex) images. Results: At baseline, there were statistically significant differences in 11C-PIB uptake, but not in cognitive test performances between the converters and nonconverters. Memory and executive function declined only in the converters during follow-up. In the converters, lower baseline frontal 11C-PIB uptake was associated with faster decline in verbal learning. Higher baseline uptake in the caudate nucleus was related to faster decline in memory consolidation, and higher temporal uptake was associated with decline in executive function. Conclusion: Higher 11C-PIB uptake in the caudate nucleus and temporal lobe was related to decline in memory and executive functions, whereas lower frontal uptake was related to decline in verbal learning. The results indicate that in prodromal AD, frontal amyloid accumulation reaches its maximum in the MCI stage, characterized by memory problems without full-blown dementia. Copyright (C) 2012 S. Karger AG, Basel


Keywords

Alzheimer's disease, Cognition, Episodic memory, Mild cognitive impairment, Pittsburgh compound B, Psychometric tests

Last updated on 2019-18-08 at 05:18