Cerebral glucose metabolism in dizygotic twin pairs discordant for Alzheimer's disease

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Virta JJ, Karrasch M, Kaprio J, Koskenvuo M, Raiha I, Viljanen T, Rinne JO
Publisher: KARGER
Publication year: 2008
Journal: Dementia and Geriatric Cognitive Disorders
Journal acronym: DEMENT GERIATR COGN
Volume number: 25
Issue number: 1
Start page: 9
End page: 16
Number of pages: 8
ISSN: 1420-8008


Abstract

Positron emission tomography (PET) with 2-deoxy-2[F-18]-fluoro-D-glucose (FDG) can be used to estimate regional cerebral glucose metabolism (rCMRgluc). FDG-PET studies have shown rCMRgluc to be reduced especially in temporal and parietal cortices in Alzheimer's disease (AD). A previous study on monozygotic twins discordant for AD showed that the rCMRgluc of the non-demented twins is reduced significantly in the lateral temporal and parietal cortices compared to unrelated controls. In this study we examined 9 pairs of dizygotic twins discordant for AD with FDG-PET. The rCMRgluc of the demented twins was 16% lower in the prefrontal cortex (p = 0.04), 20% lower in the hippocampus (p = 0.002) and 15% lower in the lateral temporal cortex (p = 0.003) compared to controls. The non-demented twins showed no such reductions on any cortical region compared to unrelated control subjects. This implies that both genes and environment, and not genes alone, are causative in the pathogenesis of AD. Copyright (c) 2007 S. Karger AG, Basel.


Keywords

Alzheimer's disease, cerebral glucose metabolism, dizygotic twins

Last updated on 2019-18-08 at 07:31