Traumatic injury to CNS fiber tracts - What are the genes telling us?

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Abankwa D, Kury P
Publisher: BENTHAM SCIENCE PUBL LTD
Publication year: 2004
Journal: Current Drug Targets
Journal acronym: CURR DRUG TARGETS
Volume number: 5
Issue number: 7
Start page: 647
End page: 654
Number of pages: 8
ISSN: 1389-4501


Abstract

In contrast to the peripheral nervous system (PNS) nerve fiber tracts of the adult central nervous system (CNS) cannot spontaneously regenerate in response to lesions. As a result injured individuals suffer from chronically impaired neuronal connections leading to major motor-, sensory- and cognitive deficits. It is generally assumed that combinatorial effects account for this regeneration failure including a growth non-permissive environment within CNS lesion zones as well as incomplete activation of axonal growth programmes. In order to design CNS repair strategies it is, therefore, imperative to address the molecular mechanisms responsible for this abortive growth behaviour by means of large scale screening techniques. This review summarizes the outcome of recent gene expression profiling studies investigating local and remote molecular reactions following CNS axotomy.


Keywords

axotomy, CNS, DNA array technology, gene expression patterns, lesion site, nerve regeneration, PNS, spinal cord injury

Last updated on 2019-17-10 at 03:11

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