Heat shock factor 1 as a coordinator of stress and developmental pathways

A3 Bokavsnitt, kapitel i forskningsböcker

Interna författare/redaktörer

Publikationens författare: Anckar J, Sistonen L
Redaktörer: Peter Csermely & Laszlo Vigh
Publiceringsår: 2007
Förläggare: Springer
Moderpublikationens namn: Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
Seriens namn: Advances in Experimental Medicine and Biology
Nummer i serien: 594
Artikelns första sida, sidnummer: 78
Artikelns sista sida, sidnummer: 88
ISBN: 978-0-387-39974-4
eISBN: 978-0-387-39975-1


The transition from normal growth conditions to stressful conditions is accompanied by a robust upregulation of heat shock proteins, which dampen the cytotoxicity caused by misfolded and denatured proteins. The most prominent part of this transition occurs on the transcriptional level. In mammals, protein-damaging stress leads to the activation of heat shock factor 1(HSF1), which binds to upstream regulatory sequences in the promoters of heat shock genes. The activation of HSF1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications. In addition to its established role as the main regulator of heat shock genes, new data link HSF1 to developmental pathways. In this chapter, we examine the established stress-related functions and prospect the intriguing role of HSF1 as a developmental coordinator.

Senast uppdaterad 2020-19-02 vid 03:18