Multisite phosphorylation provides sophisticated regulation of transcription factors

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Holmberg CI, Tran SEF, Eriksson JE, Sistonen L
Publication year: 2002
Journal: Trends in Biochemical Sciences
Journal acronym: TRENDS BIOCHEM SCI
Volume number: 27
Issue number: 12
Start page: 619
End page: 627
Number of pages: 9
ISSN: 0968-0004
eISSN: 1362-4326


Reversible phosphorylation is a prevalent mechanism by which the activity of eukaryotic transcription factors is regulated rapidly in response to changes in the cellular environment. Accumulated evidence has expanded the concept of phosphorylation to a process that provides dynamic and precise tuning of the transactivating potential of a factor, rather than being a static on/off switch. In the case of transcription factors such as heat shock factor 1 (HSF1), p53 and nuclear factor of activated T cells (NFAT), multisite phosphorylation enables several effects to operate within a single factor, thereby functioning as a key to signal integration. Studies on these transcription factors illustrate recent progress in solving the dynamic nature of transcriptional regulation by multisite phosphorylation.

Last updated on 2020-24-02 at 03:17