Ras nanoclusters: Molecular structure and assembly

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Abankwa D, Gorfe AA, Hancock JF
Förläggare: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Publiceringsår: 2007
Tidskrift: Seminars in Cell and Developmental Biology
Tidskriftsakronym: SEMIN CELL DEV BIOL
Volym: 18
Nummer: 5
Artikelns första sida, sidnummer: 599
Artikelns sista sida, sidnummer: 607
Antal sidor: 9
ISSN: 1084-9521


Abstrakt

H-, N- and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding proteins. Recent work has shown that Ras proteins are laterally segregated into non-overlapping, dynamic domains of the plasma membrane called nanoclusters. This lateral segregation is important to specify Ras interactions with membrane-associated proteins, effectors and scaffolding proteins and is critical for Ras signal transduction. Here we review biological, in vitro and structural data that provide insight into the molecular basis of how palmitoylated Ras proteins are anchored to the plasma membrane. We explore possible mechanisms for how the interactions of H-ras with a lipid bilayer may drive nanocluster formation. (C) 2007 Elsevier Ltd. All rights reserved.


Nyckelord

lipid-raft, MD simulations, nanocluster, Ras, structure

Senast uppdaterad 2019-10-12 vid 03:48