Ras nanoclusters: Molecular structure and assembly

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Abankwa D, Gorfe AA, Hancock JF
Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Publication year: 2007
Journal: Seminars in Cell and Developmental Biology
Journal acronym: SEMIN CELL DEV BIOL
Volume number: 18
Issue number: 5
Start page: 599
End page: 607
Number of pages: 9
ISSN: 1084-9521


Abstract

H-, N- and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding proteins. Recent work has shown that Ras proteins are laterally segregated into non-overlapping, dynamic domains of the plasma membrane called nanoclusters. This lateral segregation is important to specify Ras interactions with membrane-associated proteins, effectors and scaffolding proteins and is critical for Ras signal transduction. Here we review biological, in vitro and structural data that provide insight into the molecular basis of how palmitoylated Ras proteins are anchored to the plasma membrane. We explore possible mechanisms for how the interactions of H-ras with a lipid bilayer may drive nanocluster formation. (C) 2007 Elsevier Ltd. All rights reserved.


Keywords

lipid-raft, MD simulations, nanocluster, Ras, structure

Last updated on 2019-26-08 at 04:58