Iron catalyzed halogenation of benzylic aldehydes and ketones

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Risto Savela, Johan Wärnå, Dmitry Yu. Murzin, Reko Leino
Publication year: 2015
Journal: Catalysis Science and Technology
Journal acronym: CATAL SCI TECHNOL
Volume number: 5
Issue number: 4
Start page: 2406
End page: 2417
Number of pages: 12
ISSN: 2044-4753
eISSN: 2044-4761


A simple and efficient iron-catalyzed method for chlorination of aromatic carbonyl compounds is reported. By using 4-10 mol% Fe(III) oxo acetate catalyst, prepared by solid state atmospheric oxidation of Fe(II) acetate, in combination with triethylsilane and chlorotrimethylsilane, hydrosilylation of benzylic carbonyl compounds with subsequent chlorination is achieved within a few hours at room temperature. This new method is mild and rapid compared to the conventional two step approach involving reduction and chlorination reactions in separate stages. Development of synthetic methodology is also supplemented here by kinetic investigation of the reaction mechanism, which supports the tentative mechanisms suggested previously for similar reactions.

Last updated on 2020-28-05 at 01:32