Canonical transient receptor potential channel 2 (TRPC2): old name-new games. Importance in regulating of rat thyroid cell physiology

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Publikationens författare: Törnquist K, Sukumaran P, Kemppainen K, Löf C, Viitanen T
Förläggare: SPRINGER
Publiceringsår: 2014
Tidskrift: Pflügers Archiv European Journal of Physiology
Tidskriftsakronym: PFLUG ARCH EUR J PHY
Volym: 466
Nummer: 11
Artikelns första sida, sidnummer: 2025
Artikelns sista sida, sidnummer: 2034
Antal sidor: 10
ISSN: 0031-6768
eISSN: 1432-2013


Abstrakt


  1. In addition to the TSH-cyclic AMP signalling pathway, calcium signalling is of crucial importance in thyroid cells. Although the importance of calcium signalling has been thoroughly investigated for several decades, the nature of the calcium channels involved in signalling is unknown. In a recent series of investigations using the well-studied rat thyroid FRTL-5 cell line, we showed that these cells exclusively express the transient receptor potential canonical 2 (TRPC2) channel. Our results suggested that the TRPC2 channel is of significant importance in regulating thyroid cell function. These investigations were the first to show that thyroid cells express a member of the TRPC family of ion channels. In this review, we will describe the importance of the TRPC2 channel in regulating TSH receptor expression, thyroglobulin maturation, intracellular calcium and iodide homeostasis and that the channel also regulates thyroid cell proliferation.


Nyckelord

Intracellular calcium, Rat, Receptor, Thyroid, TRPC2, TSH

Senast uppdaterad 2019-22-11 vid 04:07