Antithrombotic properties of sulfated wood-derived galactoglucomannans

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Ales Doliska, Stefan Willför, Simona Strnad, Volker Ribitsch, Karin Stana Kleinschek, Patrik Eklund, Chunlin Xu
Förläggare: WALTER DE GRUYTER GMBH
Publiceringsår: 2012
Tidskrift: Holzforschung
Tidskriftsakronym: HOLZFORSCHUNG
Volym: 66
Nummer: 2
Artikelns första sida, sidnummer: 149
Artikelns sista sida, sidnummer: 154
Antal sidor: 6
ISSN: 0018-3830


Abstrakt

Galactoglucomannans (GGMs) are water-soluble polysaccharides released and accumulated in process waters in the production of thermomechanical pulp. The general trend in the forestry industry is moving towards bio-refineries, for example utilizing these hemicelluloses as bioactive substances. At present, there is no industrial use of wood-derived mannans. In this study, GGMs extracted from thermomechanical pulp, as well as further carboxymethylated galactoglucomannans (CM-GGMs), were sulfated to increase their antithrombotic properties. The products were characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance and capillary electrophoresis. The carbohydrate composition and sulfur amounts were determined. The products' total charges were determined by polyelectrolyte titrations and their antithrombotic effect was measured based on the activated partial thromboplastin time. The results showed a significant increase in the antithrombotic effect of the sulfated galactoglucomannans from spruce wood and thus a potential new use for wood-derived mannans.


Nyckelord

activated partial thromboplastin time, anticoagulant, antithrombocity, carboxymethylation, galactoglucomannan, spruce wood, sulfated polysaccharide

Senast uppdaterad 2020-06-07 vid 05:03