Proteomic analysis of breast tumors confirms the mRNA intrinsic molecular subtypes using different classifiers: a large-scale analysis of fresh frozen tissue samples

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Waldemarson S, Kurbasic E, Krogh M, Cifani P, Berggard T, Borg A, James P
Förläggare: BIOMED CENTRAL LTD
Publiceringsår: 2016
Tidskrift: Breast Cancer Research
Tidskriftsakronym: BREAST CANCER RES
Volym: 18
Antal sidor: 14
ISSN: 1465-542X
eISSN: 1465-542X


Abstrakt

Conclusions: This work demonstrates the merits of protein expression profiling for breast cancer stratification. These findings have important implications for the use of genomics and expression analysis for the prediction of protein expression, such as receptor status and drug target expression. The highly multiplexed MS assay is easily implemented in standard clinical chemistry practice, allowing rapid and cheap characterization of tumor tissue suitable for directing the choice of treatment.


Nyckelord

Breast cancer, Mass spectrometry, Molecular subtyping, Proteomics, Transcriptomics

Senast uppdaterad 2019-22-11 vid 04:10