Proteomic analysis of breast tumors confirms the mRNA intrinsic molecular subtypes using different classifiers: a large-scale analysis of fresh frozen tissue samples

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Waldemarson S, Kurbasic E, Krogh M, Cifani P, Berggard T, Borg A, James P
Publisher: BIOMED CENTRAL LTD
Publication year: 2016
Journal: Breast Cancer Research
Journal acronym: BREAST CANCER RES
Volume number: 18
Number of pages: 14
ISSN: 1465-542X
eISSN: 1465-542X


Abstract

Conclusions: This work demonstrates the merits of protein expression profiling for breast cancer stratification. These findings have important implications for the use of genomics and expression analysis for the prediction of protein expression, such as receptor status and drug target expression. The highly multiplexed MS assay is easily implemented in standard clinical chemistry practice, allowing rapid and cheap characterization of tumor tissue suitable for directing the choice of treatment.


Keywords

Breast cancer, Mass spectrometry, Molecular subtyping, Proteomics, Transcriptomics

Last updated on 2019-15-10 at 02:45