Rhamnosylation of lignans by a Streptomyces strain

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Patrik Eklund, Toni Holmström, Lamis Al-Ubaydy, Rainer Sjöholm, Juha Hakala
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 2006
Journal: Tetrahedron Letters
Journal acronym: TETRAHEDRON LETT
Volume number: 47
Issue number: 10
Start page: 1645
End page: 1648
Number of pages: 4
ISSN: 0040-4039


Abstract

Screening of 400 Streptomyces strains for biotransformation of the natural lignan matairesinol led to the identification of Streptomyces sp. LS136, capable of producing a single metabolite in moderate yields. Isolation and purification by preparative HPLC, followed by structural analyses by LC-MS and NMR, established the structure as matairesinol-4-O-rhamnoside. This bacterial strain was also used for rhamnosylation of the abundant natural lignans, hydroxymatairesinol and secoisolariciresinol. (c) 2006 Elsevier Ltd. All rights reserved.

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