In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use

A2 Review article, Literature review, Systematic review


Internal Authors/Editors


Publication Details

List of Authors: Olof Eriksson, Maren Laughlin, Maarten Brom, Pirjo Nuutila, MIchael Roden, Albert Hwa, Riccardo Bonadonna, Martin Gotthardt
Publisher: SPRINGER
Publication year: 2016
Journal: Diabetologia
Journal acronym: DIABETOLOGIA
Volume number: 59
Issue number: 7
Start page: 1340
End page: 1349
Number of pages: 10
ISSN: 0012-186X


Abstract

Radiotracer imaging is characterised by high in vivo sensitivity, with a detection limit in the lower picomolar range. Therefore, radiotracers represent a valuable tool for imaging pancreatic beta cells. High demands are made of radiotracers for in vivo imaging of beta cells. Beta cells represent only a small fraction of the volume of the pancreas (usually 1-3%) and are scattered in the tiny islets of Langerhans throughout the organ. In order to be able to measure a beta cell-specific signal, one has to rely on highly specific tracer molecules because current in vivo imaging technologies do not allow the resolution of single islets in humans non-invasively. Currently, a considerable amount of preclinical data are available for several radiotracers and three are under clinical evaluation. We summarise the current status of the evaluation of these tracer molecules and put forward recommendations for their further evaluation.


Keywords

Beta cell, Beta cell imaging, Diabetes, Exendin, Islet imaging, Islets of Langerhans, PET, SPECT

Last updated on 2019-22-09 at 03:40