Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the beta-(1 -> 2)-Linked Cell Wall Mannans of Candida albicans

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Kaarina Ranta, Kaisa Nieminen, Filip S. Ekholm, Moniká Poláková, Mattias U.Roslund, Tiina Saloranta, Reko Leino and Johannes Savolainen
Förläggare: AMER SOC MICROBIOLOGY
Publiceringsår: 2012
Tidskrift: Clinical and Vaccine Immunology
Tidskriftsakronym: CLIN VACCINE IMMUNOL
Volym: 19
Nummer: 11
Artikelns första sida, sidnummer: 1889
Artikelns sista sida, sidnummer: 1893
Antal sidor: 5
ISSN: 1556-6811


Abstrakt

Immunostimulatory properties of synthetic structures mimicking the beta-(1 -> 2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(alpha-D-mannopyranosyloxy) butane induced TNF and some molecules induced low levels of gamma interferon (IFN-gamma) in human peripheral blood mononuclear cells (PBMC).

Senast uppdaterad 2020-20-02 vid 06:57