Enabling flexible dosing in orodispersible paediatric formulations by means of solvent casting and thermal inkjet printing

B1 Non-refereed journal articles


Internal Authors/Editors


Publication Details

List of Authors: Heidi Öblom, Ines Pollmann, Diti Desai, Ezgi Özliseli, Jessica Rosenholm, Maren Preis
Editors: Smita Salunke, Catherine Tuleu
Publication year: 2018
Journal: International Journal of Pharmaceutics
Book title: Formulating Better Medicines for Children – European Paediatric Formulation Initiative (EuPFI) 2016
Volume number: 536
Start page: 495
End page: 496


Abstract

Introduction: Providing and enabling flexible dosing options for drugs with a specific need in the paediatric population is a major topic in the recent years. Innovative approaches regarding orodispersible dosage form for paediatric use became more and more popular (Preis, 2015). Latest research includes the application of printing technologies by using drug-loaded inks to obtain even more flexibility with regard to individual dosing (Preis and Sandler, 2016).

Purpose: The purpose of this study was to investigate different methods to prepare drug-loaded orodispersible films. Besides the conventional preparation using a solvent casting approach using the pure drug and drug-loaded mesoporous nanoparticles, the suitability to use a readily available desktop thermal inkjet printer to load drug-free films with variable doses for paediatrics was studied.

Conclusion: Two drugs with a specific need for paediatric formulations were successfully processed in orodispersible films. The inkjet printing procedure could be shown as a convenient method to obtain a variety of doses. Furthermore, printing of dosage forms


Last updated on 2019-22-10 at 03:32