A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Roberta Bernini, Giampiero Gualandi, Claudia Crestini, Maurizio Barontini, Maria Cristina Belfiore, Stefan Willför, Patrik Eklund, Raffaele Saladino
Förläggare: PERGAMON-ELSEVIER SCIENCE LTD
Publiceringsår: 2009
Tidskrift: Bioorganic and Medicinal Chemistry
Tidskriftsakronym: BIOORGAN MED CHEM
Volym: 17
Nummer: 15
Artikelns första sida, sidnummer: 5676
Artikelns sista sida, sidnummer: 5682
Antal sidor: 7
ISSN: 0968-0896


Abstrakt

Highly oxidized lignans produced during the cytochrome P-450 metabolism in the cells show biological activities significantly different from those of their parent natural compounds. Lignans precursors of mammalian enterolignans were treated with a methyltrioxorhenium/hydrogen peroxide catalytic system to afford new compounds oxidized at benzylic as well as in arylic positions. The evaluation of the antioxidant and apoptogenic activity by in vivo protocols of these compounds showed some interesting structure-activity relationships related to the oxidation degree of the molecules. (C) 2009 Elsevier Ltd. All rights reserved.


Nyckelord

Antioxidant activity, Apoptogenic activity, Ethanol Oxidation, Lignans, Methyltrioxorhenium

Senast uppdaterad 2020-27-01 vid 04:36