Two-step synthesis of monoterpenoid dioxinols exhibiting analgesic activity from isopulegol and benzaldehyde over heterogeneous catalysts

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Martina Stekrova, Päivi Mäki-Arvela, Ewelina Leino, Karolina M. Valkaj, Kari Eränen, Atte Aho, Annika Smeds, Narendra Kumar, Konstantin P. Volcho, Nariman F. Salakhutdinov, Dmitry Yu. Murzin
Publication year: 2017
Journal: Catalysis Today
Volume number: 279, Part 1
Start page: 56
End page: 62
eISSN: 1873-4308


Benzodioxinols, compounds with 6-membered heterocycles containing two oxygen atoms, exhibit promising analgesic activity. In the current study, synthesis of dioxinol via two-step approach including Prins cyclization of isopulegol with benzaldehyde to tetrahydropyran and its ring-rearrangement to dioxinol was investigated. Different acidic and basic catalysts were studied in the second step and the highest selectivity toward dioxinol was achieved using mesoporous Ce-composite material.


engineering education

Last updated on 2020-26-09 at 02:52