The effect of fibrin sealant on bioactive glass S53P4 particles – pH impact and dissolution characteristics in vitro

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Jussi Sarin, Leena Björkvik, Markus Hiltunen, Leena Hupa, Jaakko Pulkkinen, Pekka K. Vallittu
Publiceringsår: 2016
Tidskrift: Journal of Science: Advanced Materials and Devices
Volym: 1
Nummer: 4
Artikelns första sida, sidnummer: 482
Artikelns sista sida, sidnummer: 487
eISSN: 2468-2179


Abstrakt

Fibrin glue, a two-component tissue adhesive, has a range of clinical indications. Bioactive glass (BG) S53P4 has been approved for clinical use in several craniomaxillofacial and orthopedic applications. Although sometimes used simultaneously, there is no data available regarding the possible interaction of these two biocompatible substances. In this in vitro study, using a BG particle concentration of 4 mg/ml, a 0.4 unit pH increment (p < 0.001) was observed in simulated body fluid (SBF) after a 7-day incubation period. The addition of fibrin glue (0.13 g, SD 0.04; or 3.7 mg/ml) on top of the BG particles raised further the pH by 0.5 units (p < 0.001). The difference between these groups was statistically significant (p = 0.008). With a BG concentration of 25 mg/ml and a fibrin glue concentration of 18 mg/ml during a 14-day incubation period, a pH increment of 0.6 units and SBF ion concentration change of Ca, K, Mg, Na, P and Si ions was seen. Moreover, a penetration depth between 4 and 6 mm was observed when fibrin glue was applied on top of a bed of BG particles. Conclusions: Fibrin glue is not likely to have a distracting effect on BG-induced pH increase of the SBF although it might delay early BG surface reactions based on ion concentration measurements. Fibrin glue penetrated to the interparticle space to some extent, binding the particles together for easy clinical use of BG.

Senast uppdaterad 2019-18-11 vid 02:07