Self-assembled semi-crystallinity at parallel β-sheet nanocrystal interfaces in clustered MaSp1 (spider silk) proteins

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Erly Sintya, Parvez Alam
Publisher: Elsevier B.V.
Publication year: 2016
Journal: Materials Science and Engineering: C
Volume number: 58
Start page: 366
End page: 371
eISSN: 1873-0191


In this communication, we use molecular dynamics methods to model the self-assembly of semi-crystalline domains at β-sheet nanocrystal interfaces in clusters of spider silk (MaSp1) proteins. Our research elucidates that the energetics at interfaces between crystalline and amorphous domains control effectively, the extent to which semi-crystalline domains can form at interfaces. Stability at nanocrystal interfaces is not linearly related to the internal (bulk) stability of the β-sheet nanocrystal. Rather, interfacial stability is found to be highly sensitive to the number of alanine repeat units that make up each sheet. Intriguingly, the most stable interface for the development of semi-crystallinity is built up of polyalanine β-sheets of a length similar to that which is spun naturally in spider dragline silk.

Last updated on 2020-02-04 at 06:58