Combination of reaction and separation in heterogeneous catalytic hydrogenation of ethylformate

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Gerson Martin, Carla Pereira, Frank Pettersson, Henrik Saxén, Dmitry Y. Murzin, Alírio Rodrigues, Tapio Salmi
Publication year: 2015
Journal: Chemical Engineering and Technology
Volume number: 38
Issue number: 5
Start page: 804
End page: 812
eISSN: 1521-4125


Abstract

Continuous hydrogenation reaction of ethyl benzoylformate was studied over a (–)-cinchonidine (CD)-modified Pt/Al2O3 catalyst. The catalyst showed a good stability, and high enantioselectivity was achieved in the fixed-bed reactor. Chromatographic separation of (R)- and (S)-ethyl mandelate originating from a post-continuous hydrogenation reaction of ethyl benzoylformate over the (–)-CD-modified Pt/Al2O3 catalyst was investigated in the same reaction mixture. A commercial column filled with a chiral selector resin was chosen as a perspective preparative-scale adsorbent. Since adsorption equilibrium isotherms were linear within the entire investigated range of concentrations, they were determined by pulse experiments for the isomers present in a post-reaction mixture. Breakthrough curves were measured and described successfully by the dispersive plug-flow model with linear driving force approximation.

Last updated on 2019-20-11 at 03:34