Assistant Professor

Hongbo Zhang

Academy Research Fellow, Pharmacy
Biträdande professor (tenure track), Biosciences
Email: hongbo.zhang@abo.fi
Mobile: +358-503061491
Phone: +358-2-2154141


Professional interests

Microfluidics, Nanomedicine, Single cell analysis, Drug delivery, Tissue engineering


Peer-reviewed publications

A1 Journal article (refereed)
Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells (2019)
Qi S, Zhang P, Ma M, Yao M, Wu J, Mäkilä E, Salonen J, Ruskoaho H, Xu Y, Santos HA, Zhang H
Small
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A1 Journal article (refereed)
Efficient Inhibition of Wear‐Debris‐Induced Osteolysis by Surface Biomimetic Engineering of Titanium Implant with a Mussel‐Derived Integrin‐Targeting Peptide (2019)
Guo X, Liu Y, Bai J, Yu B, Xu M, Sun H, Shen J, Lin J, Zhang H, Wang D, Geng D, Pan G
Advanced Biosystems
Advanced Science
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A2 Review article, Literature review, Systematic review
Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases (2019)
Yueqi Zhu, Hongbo Zhang, Yiran Zhang, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng, Minghua Li, Hélder A. Santos, Wenguo Cui
Advanced Materials
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A1 Journal article (refereed)
Euryale Ferox Seed‐Inspired Superlubricated Nanoparticles for Treatment of Osteoarthritis (2019)
Yan Y, Sun T, Zhang H, Ji X, Sun Y, Zhao X, Deng L, Qi J, Cui W, Santos HA
Advanced Functional Materials
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A1 Journal article (refereed)
Fabrication of Redox- Responsive Doxorubicin and Paclitaxel Prodrug Nanoparticles with Microfluidics for Selective Cancer Therapy (2019)
Xiaodong Ma, Ezgi Özliseli, Yuezhou Zhang, Guoqing Pan, Dongqing Wang,Hongbo Zhang
Biomaterials Science
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A1 Journal article (refereed)
Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration (2019)
Mao X, Cheng R, Zhang H, Bae J, Cheng L, Zhang L, Deng L, Cui W, Zhang Y, Santos HA, Sun X
View on publisher's site
A1 Journal article (refereed)
Vascularized 3D printed scaffolds for promoting bone regeneration (2019)
Yufei Yan, Hao Chen, Hongbo Zhang,Changjun Guo, Kai Yang, Kaizhe Chen, Ruoyu Cheng, Niandong Qian, Niklas Sandler, Yu Shrike Zhang, Haokai Shen, Jin Qi, Wenguo Cui, Lianfu Deng
Biomaterials
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A1 Journal article (refereed)
Adjustable hardness of hydrogel for promoting vascularization and maintaining stemness of stem cells in skin flap regeneration (2018)
Sun X, Zhang H, He J, Cheng R, Cao Y, Che K, Cheng L, Zhang L, Pan G, Ni P, Deng L, Zhang Y, Santos HA, Cui W
Applied Materials Today
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A1 Journal article (refereed)
An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration (2018)
Liu X, Zhang H, Cheng R, Gu Y, Yin Y, Sun Z, Pan G, Deng Z, Yang H, Deng L, Cui W, Santos HA, Shi Q
Materials Horizons
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A1 Journal article (refereed)
Cell Membrane-Based Nanoreactor To Mimic the Bio-Compartmentalization Strategy of a Cell (2018)
Balasubramanian V, Poillucci A, Correia A, Zhang H, Celia C, Santos HA
ACS Biomaterials Science and Engineering
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A2 Review article, Literature review, Systematic review
Current developments and applications of microfluidic technology toward clinical translation of nanomedicines (2018)
Liu D, Zhang H, Fontana F, Hirvonen JT, Santos HA
Advanced Drug Delivery Reviews
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A1 Journal article (refereed)
Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates (2018)
Zhang H, Zhu Y, Qu L, Wu H, Kong H, Yang Z, Chen D, Mäkilä E, Salonen J, Santos HA, Hai M, Weitz DA
Nano Letters
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A1 Journal article (refereed)
Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine (2018)
Li W, Li Y, Liu Z, Kerdsakundee N, Zhang M, Zhang F, Liu X, Bauleth-Ramos T, Lian W, Mäkilä E, Kemell M, Ding Y, Sarmento B, Wiwattanapatapee R, Salonen J, Zhang H, Hirvonen JT, Liu D, Deng X, Santos HA
Biomaterials
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A1 Journal article (refereed)
Impact of pore size and surface chemistry of porous silicon particles and structure of phospholipids on their interactions (2018)
Liu D, Lipponen K, Quan P, Wan X, Zhang H, Mäkilä EM, Salonen JJ, Kostiainen R, Hirvonen JJ, Kotiaho T, Santos HA
ACS Biomaterials Science and Engineering
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A1 Journal article (refereed)
Light-Activatable Assembled Nanoparticles to Improve Tumor Penetration and Eradicate Metastasis in Triple Negative Breast Cancer (2018)
Ji JF, Ma F, Zhang HB, Liu FY, He J, Li WL, Xie TT, Zhong DN, Zhang TT, Tian M, Zhang H, Santos HA, Zhou M
Advanced Functional Materials
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A1 Journal article (refereed)
Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence (2018)
Xia G, Zhang H, Cheng R, Wang H, Song Z, Deng L, Huang X, Santos HA, Cui W
Advanced Healthcare Materials
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A1 Journal article (refereed)
Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle (2018)
Zoran Cenev, Hongbo Zhang, Veikko Sariola, Antti Rahikkala, Dongfei Liu, Hélder A. Santos, Quan Zhou
Advanced Materials Technologies
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A1 Journal article (refereed)
Mesopore-Induced Aggregation of Cobalt Protoporphyrin for Photoacoustic Imaging and Antioxidant Protection of Stem Cells (2018)
Yao MH, Ma M, Zhang HB, Zhang YZ, Wan G, Shen J, Chen HR, Wu R
Advanced Functional Materials
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A2 Review article, Literature review, Systematic review
Programmable and Multifunctional DNA-Based Materials for Biomedical Applications (2018)
Zhang Y, Tu J, Wang D, Zhu H, Maity SK, Qu X, Bogaert B, Pei H, Zhang H
Advanced Materials
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A1 Journal article (refereed)
Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors (2018)
Zhong RB, Tang Q, Wang SP, Zhang HB, Zhang F, Xiao MS, Man TT, Qu XM, Li L, Zhang WJ, Pei H
Advanced Materials
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A1 Journal article (refereed)
Sequential Antifouling Surface for Efficient Modulation of the Nanoparticle–Cell Interactions in Protein‐Rich Environments (2018)
Zhang F, Kong L, Liu D, Li W, Mäkilä E, Correia A, Lindgren R, Salonen J, Hirvonen JJ, Zhang H, Kros A, Santos HA
Advanced therapeutics
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A1 Journal article (refereed)
A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging (2017)
Janoniene A, Liu Z, Baranauskiene L, Mäkilä E, Ma M, Salonen J, Hirvonen J, Zhang H, Petrikaite V, Santos HA
ACS Applied Materials and Interfaces
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A1 Journal article (refereed)
Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle‐Like Functions (2017)
Balasubramanian V, Correia A, Zhang H, Fontana F, Mäkilä E, Salonen J, Hirvonen J, Santos HA
Advanced Materials
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A1 Journal article (refereed)
Bubble-Mediated Ultrasensitive Multiplex Detection of Metal Ions in Three-Dimensional DNA Nanostructure-Encoded Microchannels (2017)
Qu X, Yang F, Chen H, Li J, Zhang H, Zhang G, Li L, Wang L, Song S, Tian Y, Pei H
ACS Applied Materials and Interfaces
Lab on a Chip
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A1 Journal article (refereed)
Convection-Driven Pull-Down Assays in Nanoliter Droplets Using Scaffolded Aptamers (2017)
Qu X, Zhang H, Chen H, Aldalbahi A, Li L, Tian Y, Weitz DA, Pei H
Analytical Chemistry
Advanced Healthcare Materials
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A1 Journal article (refereed)
Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation (2017)
Liu D, Zhang H, Cito S, Fan J, Mäkilä E, Salonen J, Hirvonen J, Sikanen TM, Weitz DA, Santos HA
Nano Letters
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A1 Journal article (refereed)
Electrospun photocrosslinkable hydrogel fibrous scaffolds for rapid in vivo vascularized skin flap regeneration (2017)
Sun X, Lang Q, Zhang H, Cheng L, Zhang Y, Pan G, Zhao X, Yang H, Zhang Y, Santos HA, Cui W
Advanced Functional Materials
Advanced Materials
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A1 Journal article (refereed)
Fabrication of Calcium Phosphate‐Based Nanocomposites Incorporating DNA Origami, Gold Nanorods, and Anticancer Drugs for Biomedical Applications (2017)
Zhang H, Qu X, Chen H, Kong H, Ding R, Chen D, Zhang X, Pei H, Santos HA, Hai M, Weitz D
Advanced Healthcare Materials
Advanced Materials
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A1 Journal article (refereed)
Microfluidic assembly of a nano-in-micro dual drug delivery platform composed of halloysite nanotubes and a pH-responsive polymer for colon cancer therapy (2017)
Li W, Liu D, Zhang H, Correia A, Mäkilä E, Salonen J, Hirvonen J, Santos HA
Acta Biomaterialia
Advanced Functional Materials
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A2 Review article, Literature review, Systematic review
Microfluidic-assisted fabrication of carriers for controlled drug delivery (2017)
Liu D, Zhang H, Fontana F, Hirvonen JT, Santos HA
View on publisher's site
A1 Journal article (refereed)
Microfluidic Encapsulation of Prickly Zinc‐Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy (2017)
Hongbo Zhang, Dongfei Liu, Liang Wang, Zehua Liu, Runrun Wu, Agne Janoniene, Ming Ma, Guoqing Pan, Lina Baranauskiene, Linlin Zhang, Wenguo Cui, Vilma Petrikaite, Daumantas Matulis, Hongxia Zhao, Jianming Pan, Hélder A. Santos
View on publisher's site
A1 Journal article (refereed)
Microfluidics platform for glass capillaries and its application in droplet and nanoparticle fabrication (2017)
Herranz-Blanco B, Ginestar E, Zhang H, Hirvonen J, Santos HA
International Journal of Pharmaceutics
A1 Journal article (refereed)
Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics (2017)
Liu Z, Li Y, Li W, Xiao C, Liu D, Dong C, Zhang M, Mäkilä E, Kemell M, Salonen J, Hirvonen J, Zhang H, Zhou D, Deng X, Santos HA
View on publisher's site
A1 Journal article (refereed)
Multistaged Nanovaccines Based on Porous Silicon@ Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy (2017)
Fontana F, Shahbazi M, Liu D, Zhang H, Mäkilä E, Salonen J, Hirvonen JT, Santos HA
View on publisher's site
A1 Journal article (refereed)
Nutlin-3a and Cytokine Co-loaded Spermine-Modified Acetalated Dextran Nanoparticles for Cancer Chemo-Immunotherapy (2017)
Bauleth-Ramos T, Shahbazi MA, Liu DF, Fontana F, Correia A, Figueiredo P, Zhang HB, Martins JP, Hirvonen JT, Granja P, Sarmento B, Santos HA
View on publisher's site
A1 Journal article (refereed)
Probing Cellular Molecules with PolyA-Based Engineered Aptamer Nanobeacon (2017)
Chen L, Chao J, Qu X, Zhang H, Zhu D, Su S, Aldalbahi A, Wang L, Pei H
ACS Applied Materials and Interfaces
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A1 Journal article (refereed)
Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility (2017)
Auvinen Henni, Zhang Hongbo. Nonappa Nonappa, Kopilow Alisa, Niemelä Elina H.; Nummelin Sami, Correia Alexandra, Santos Hélder A., Linko Veikko, Kostiainen Mauri A.
Advanced Healthcare Materials
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A1 Journal article (refereed)
Quercetin‐Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin‐Resistant Cancer Cells (2017)
Liu Z, Balasubramanian V, Bhat C, Vahermo M, Mäkilä E, Kemell M, Fontana F, Janoniene A, Petrikaite V, Salonen J, Yli‐Kauhaluoma J, Hirvonen J, Zhang H, Santos HA
Advanced Healthcare Materials
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A1 Journal article (refereed)
Real-time continuous identification of greenhouse plant pathogens based on recyclable microfluidic bioassay system (2017)
Qu X, Li M, Zhang H, Lin C, Wang F, Xiao M, Zhou Y, Shi J, Aldalbahi A, Pei H, Chen H, Li L
ACS Applied Materials and Interfaces
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A1 Journal article (refereed)
Receptor-Mediated Surface Charge Inversion Platform Based on Porous Silicon Nanoparticles for Efficient Cancer Cell Recognition and Combination Therapy (2017)
Zhang F, Correia A, Mäkilä E, Li W, Salonen J, Hirvonen JJ, Zhang H, Santos HA
ACS Applied Materials and Interfaces
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A2 Review article, Literature review, Systematic review
Tailored approaches in drug development and diagnostics: from molecular design to biological model systems (2017)
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A. Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M. H. Salo-Ahen, Ronald Österbacka, John E. Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler
Advanced Healthcare Materials
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A1 Journal article (refereed)
The impact of porous silicon nanoparticles on human cytochrome P450 metabolism in human liver microsomes in vitro (2017)
Ollikainen E, Liu D, Kallio A, Mäkilä E, Zhang H, Salonen J, Santos HA, Sikanen TM
European Journal of Pharmaceutical Sciences
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A1 Journal article (refereed)
An In Situ Gelling Drug Delivery System for Improved Recovery after Spinal Cord Injury (2016)
Liu D, Jiang T, Cai W, Chen J, Zhang H, Hietala S, Santos HA, Yin G, Fan J
Advanced Healthcare Materials
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A1 Journal article (refereed)
Antibacterial Nanoparticles: Spatio‐Design of Multidimensional Prickly Zn‐Doped CuO Nanoparticle for Efficient Bacterial Killing (Adv. Mater. Interfaces 18/2016) (2016)
Wu R, Zhang H, Pan J, Zhu H, Ma Y, Cui W, Santos HA, Pan G
Advanced Materials Interfaces
A1 Journal article (refereed)
Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine Based on 3D Tumor Models (2016)
Guo H, Liu D, Gao B, Zhang X, You M, Ren H, Zhang H, Santos HA, Xu F
Molecules
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A1 Journal article (refereed)
Biodegradable Photothermal and pH Responsive Calcium Carbonate@ Phospholipid@ Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications (2016)
Kong F, Zhang H, Zhang X, Liu D, Chen D, Zhang W, Zhang L, Santos HA, Hai M
Advanced Functional Materials
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A1 Journal article (refereed)
Drug Co‐Delivery: Biodegradable Photothermal and pH Responsive Calcium Carbonate@ Phospholipid@ Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications (Adv. Funct. Mater. 34/2016) (2016)
Kong F, Zhang H, Zhang X, Liu D, Chen D, Zhang W, Zhang L, Santos HA, Hai M
Advanced Functional Materials
A1 Journal article (refereed)
Drug Delivery: Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle‐functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy (Adv. Mater. 46/2016) (2016)
Kong F, Zhang H, Qu X, Zhang X, Chen D, Ding R, Mäkilä E, Salonen J, Santos HA, Hai M
Advanced Materials
A1 Journal article (refereed)
Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle‐functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy (2016)
Kong F, Zhang H, Qu X, Zhang X, Chen D, Ding R, Mäkilä E, Salonen J, Santos HA, Hai M
Advanced Materials
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A1 Journal article (refereed)
In vitro and in vivo assessment of heart-homing porous silicon nanoparticles (2016)
Ferreira MP, Ranjan S, Correia AM, Mäkilä EM, Kinnunen SM, Zhang H, Shahbazi M, Almeida PV, Salonen JJ, Ruskoaho HJ, Airaksinen AJ, Hirvonen JT, Santos HA
Biomaterials
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A1 Journal article (refereed)
Neovascularization: Upregulating Hif‐1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound (Adv. Healthcare Mater. 8/2016) (2016)
Chen H, Jia P, Kang H, Zhang H, Liu Y, Yang P, Yan Y, Zuo G, Guo L, Jiang M, Qi J, Liu Y, Cui W, Santos HA, Deng L
Advanced Healthcare Materials
A1 Journal article (refereed)
Spatio‐Design of Multidimensional Prickly Zn‐Doped CuO Nanoparticle for Efficient Bacterial Killing (2016)
Wu R, Zhang H, Pan J, Zhu H, Ma Y, Cui W, Santos HA, Pan G
Advanced Materials Interfaces
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A1 Journal article (refereed)
Upregulating Hif-1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound (2016)
Chen, H., Jia, P., Kang, H., Zhang, H., Liu, Y., Yang, P., Yan, Y., Zuo, G., Guo, L., Jiang, M., Qi, J., Liu, Y., Cui, W., Santos, H. A. & Deng, L
Advanced Healthcare Materials


Other publications

O2 Other
Back Cover: Programmable and Multifunctional DNA‐Based Materials for Biomedical Applications (2018)
Zhang Y, Tu J, Wang D, Zhu H, Maity S, Qu X, Bogaert B, Pei H, Zhang H
Advanced Materials
O2 Other
Front cover - Cancer Therapy: Light‐Activatable Assembled Nanoparticles to Improve Tumor Penetration and Eradicate Metastasis in Triple Negative Breast Cancer (2018)
Ji J, Ma F, Zhang H, Liu F, He J, Li W, Xie T, Zhong D, Zhang T, Tian M
Advanced Functional Materials
O2 Other
Nanohybrids: Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics (Adv. Mater. 24/2018) (2018)
Liu Z, Li Y, Li W, Xiao C, Liu D, Dong C, Zhang M, Mäkilä E, Kemell M, Salonen J, Hirvonen JT, Zhang H, Zhou D, Deng X, Santos HA
Advanced Materials
O2 Other
Nanoreactors: Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle‐Like Functions (Cover) (2017)
Balasubramanian V, Correia A, Zhang H, Fontana F, Mäkilä E, Salonen J, Hirvonen J, Santos HA
Advanced Materials

Last updated on 2018-30-11 at 14:24